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. 2006 Nov 20;51(2):689–695. doi: 10.1128/AAC.00879-06

TABLE 2.

Effect of duration of treatment with ST-246 on the mortality of BALB/c mice inoculated intranasally with cowpox virus, strain BR, or vaccinia virus, strain WR

Treatmenta Cowpox virus, strain BR
Vaccinia virus, strain WR
No. of mice that died/total no. of mice (%) P value MDDb P value No. of mice that died/total no. of mice (%) P value MDD P value
5-day duration, +4 h
    Vehicle 15/15 (100) 9.1 15/15 (100) 6.1
    ST-246 100 mg/kg 13/15 (87) NSc 11.6 0.001 2/15 (13) <0.001 3.0 <0.05
5-day duration, +24 h
    Vehicle 15/15 (100) 8.6 15/15 (100) 6.3
    ST-246 100 mg/kg 11/15 (73) NS 12.4 <0.001 1/15 (7) <0.001 3.0 0.08
    CDV 15 mg/kg 0/15 (0) <0.001 1/15 (7) <0.001 15.0 0.08
7-day duration, +4 h
    Vehicle 15/15 (100) 8.2 15/15 (100) 5.7
    ST-246 100 mg/kg 1/15 (7) <0.001 5.0 0.08 3/15 (20) <0.001 6.3 NS
7-day duration, +24 h
    Vehicle 15/15 (100) 8.5 15/15 (100) 6.3
    ST-246 100 mg/kg 6/15 (40) 0.001 9.3 NS 1/15 (7) <0.001 11.0 0.09
10-day duration, +4 h
    Vehicle 15/15 (100) 8.3 15/15 (100) 6.1
    ST-246 100 mg/kg 4/15 (27) <0.001 8.0 NS 5/15 (33) <0.001 10.6 0.06
10-day duration, +24 h
    Vehicle 15/15 (100) 7.9 15/15 (100) 6.1
    ST-246 100 mg/kg 6/15 (40) 0.001 13.2 <0.01 0/15 (0) <0.001
14-day duration, +4 h
    Vehicle 14/15 (93) 9.1 15/15 (100) 5.6
    ST-246 100 mg/kg 1/15 (7) <0.001 3.0 0.09 3/15 (20) <0.001 5.3 0.05
14-day duration, +24 h
    Vehicle 15/15 (100) 8.5 15/15 (100) 6.7
    ST-246 100 mg/kg 0/15 (0) <0.001 1/15 (7) <0.001 3.0 0.09
a

ST-246 was supplied by SIGA, prepared in 0.75% methyl cellulose and 1% Tween 80, and delivered orally in 0.2-ml doses. CDV was prepared in sterile saline and given i.p. in 0.1-ml doses. Animals were treated once daily for 5, 7, 10, or 14 days beginning 4 or 24 h after viral inoculation (+4 h or +24 h, respectively).

b

MDD, mean day of death.

c

NS, not significant when compared to the appropriate vehicle control.