Figure 3.
Development of acute kidney injury during experimental septic peritonitis is not affected by TLR4-deficiency. Serum samples were obtained before (0 hr) and 12 hr after CASP surgery of wildtype C3H/HeN (TLR4+/+) and TLR4-deficient C3H/HeJ mice (TLR4d/d). Statistical analysis indicated that serum levels of creatinine and urea nitrogen were not significantly different between the two experimental groups (both at 0 hr and 12 hr). The differences between the 0 hr and 12 hr time points were statistically significant in all cases (P < 0·05).