Table 2.
Susceptibility loci containing inhibitory receptors in mouse models of autoimmune disease
| Inhibitory receptors and related molecules | Chromosome position | Mouse strain | Disease | Locus name (position) | Reference |
|---|---|---|---|---|---|
| FcγRIIb | 1 92·3 | NZB | SLE | Nba2 (1 95) | 88 |
| Lbw7 (1 90) | 37 | ||||
| NZW | Sle1 (1 88) | 38 | |||
| BXSB | Bxs3 (1100) | 89 | |||
| NOD | BCG-induced SLE | Babs2, Bana3 (1 95) | 90 | ||
| NODx | Collagen-induced arthritis* | Cia9 (1 92·3) | 91 | ||
| C57BL/10 | |||||
| CD22 | 7 9 | NZW | SLE | Sle3 (7 15) | 18 |
| CD66a | 7 5·5 | NOD | IDDM | Idd7 (7 4) | 40 |
| PIR-B | 7 1 | SJL/J | EAE† | Eae12 (7 16) | 41 |
| CD72 | 4 22·5 | NZBW/F1 | SLE | Lbw3 (4 23) | 37 |
| SHP-1 | 6 60·2 | NZBW/F1 | SLE | Lbw4 (6 71) | 37 |
| DBA | Collagen-induced arthritis* | Cia3 (6 48·7) | 75 | ||
| NOD | IDDM | Idd19 (6 60·5) | 76 |
*
Mouse model of rheumatoid arthritis.
†
Mouse model of multiple sclerosis.