Table 2.
Known proinsulin/insulin target epitopes in autoimmune diabetes
| Epitope 48–62 (B chain/C-peptide junction, aa B24-C36) | |
| ″Ins2 | FFYTPMSEVEDPQ |
| ″Ins1 | FFYTPKSEVEDPQ |
| Epitope 33–47 (B chain aa 9–23, also includes epitope 15–23) | |
| ″Ins2 | SHLVEALYLVCGERG |
| ″Ins1 | PHLVKALYLVCGERG |
| Epitope 14–30 (signal peptide aa 14–20, B chain aa 1–6) | |
| ″Ins2 | LLFLWESHPTQAFVKQHL |
| ″Ins1 | LLALWEPKPTQAFVKQHL |
| Epitope 20–35 (signal peptide aa 20, B chain aa 1–11) | |
| ″Ins2 | HPTQAFVKQHLCGSHL |
| ″Ins1 | KPTQAFVKQHLCGPHL |
| Epitope 71–88 (C-peptide) | |
| ″Ins2 | GPGAGDLQTLALEVAQQK |
| ″Ins1 | SPG**DLQTLALEVARQK |
| Epitope 88–103 (A chain) | |
| ″Ins2 | KRGIVDQCCTSICSLY |
| ″Ins1 | KRGIVDQCCTSICSLY |