Figure 2.
Effect of cytokines on DNA synthesis in pancreatic stellate cells (PSCs). Data are expressed as per cent of control (mean (SEM); n=5 separate cell preparations). (A) Tumour necrosis factor α (TNF-α) significantly increased DNA synthesis in PSCs to a maximum of 144 (13)% of control levels. (B) Interleukin (IL)-1 had no effect on DNA synthesis in PSCs. (C) IL-6, at a concentration of 10 ng/ml, inhibited DNA synthesis in PSCs, as demonstrated by a decrease in 3H thymidine incorporation to 72 (14)% of control. (D) IL-10 had no effect on DNA synthesis in PSCs.