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. 2000 Oct;55(Suppl 2):S45–S47. doi: 10.1136/thorax.55.suppl_2.S45

Genetics of aspirin induced asthma

M Sanak, A Szczeklik
PMCID: PMC1765951  PMID: 10992557

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bochenek G., Nizankowska E., Szczeklik A. The atopy trait in hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy. 1996 Jan;51(1):16–23. doi: 10.1111/j.1398-9995.1996.tb04544.x. [DOI] [PubMed] [Google Scholar]
  2. Christie P. E., Tagari P., Ford-Hutchinson A. W., Charlesson S., Chee P., Arm J. P., Lee T. H. Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects. Am Rev Respir Dis. 1991 May;143(5 Pt 1):1025–1029. doi: 10.1164/ajrccm/143.5_Pt_1.1025. [DOI] [PubMed] [Google Scholar]
  3. In K. H., Asano K., Beier D., Grobholz J., Finn P. W., Silverman E. K., Silverman E. S., Collins T., Fischer A. R., Keith T. P. Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription. J Clin Invest. 1997 Mar 1;99(5):1130–1137. doi: 10.1172/JCI119241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Israel E., Fischer A. R., Rosenberg M. A., Lilly C. M., Callery J. C., Shapiro J., Cohn J., Rubin P., Drazen J. M. The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. Am Rev Respir Dis. 1993 Dec;148(6 Pt 1):1447–1451. doi: 10.1164/ajrccm/148.6_Pt_1.1447. [DOI] [PubMed] [Google Scholar]
  5. Jakobsson P. J., Thorén S., Morgenstern R., Samuelsson B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7220–7225. doi: 10.1073/pnas.96.13.7220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kim J. B., Sarraf P., Wright M., Yao K. M., Mueller E., Solanes G., Lowell B. B., Spiegelman B. M. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J Clin Invest. 1998 Jan 1;101(1):1–9. doi: 10.1172/JCI1411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kowalski M. L., Sliwinska-Kowalska M., Igarashi Y., White M. V., Wojciechowska B., Brayton P., Kaulbach H., Rozniecki J., Kaliner M. A. Nasal secretions in response to acetylsalicylic acid. J Allergy Clin Immunol. 1993 Feb;91(2):580–598. doi: 10.1016/0091-6749(93)90264-g. [DOI] [PubMed] [Google Scholar]
  8. Lam B. K., Penrose J. F., Freeman G. J., Austen K. F. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7663–7667. doi: 10.1073/pnas.91.16.7663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lockey R. F., Rucknagel D. L., Vanselow N. A. Familial occurrence of asthma, nasal polyps and aspirin intolerance. Ann Intern Med. 1973 Jan;78(1):57–63. doi: 10.7326/0003-4819-78-1-57. [DOI] [PubMed] [Google Scholar]
  10. Miller F. F. Aspirin-induced bronchial asthma in sisters. Ann Allergy. 1971 May;29(5):263–265. [PubMed] [Google Scholar]
  11. Nasser S. M., Pfister R., Christie P. E., Sousa A. R., Barker J., Schmitz-Schumann M., Lee T. H. Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects. Am J Respir Crit Care Med. 1996 Jan;153(1):90–96. doi: 10.1164/ajrccm.153.1.8542168. [DOI] [PubMed] [Google Scholar]
  12. Sanak M., Simon H. U., Szczeklik A. Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma. Lancet. 1997 Nov 29;350(9091):1599–1600. doi: 10.1016/s0140-6736(05)64015-9. [DOI] [PubMed] [Google Scholar]
  13. Szczeklik A. Aspirin-induced asthma as a viral disease. Clin Allergy. 1988 Jan;18(1):15–20. doi: 10.1111/j.1365-2222.1988.tb02838.x. [DOI] [PubMed] [Google Scholar]
  14. Szczeklik A., Sladek K., Dworski R., Nizankowska E., Soja J., Sheller J., Oates J. Bronchial aspirin challenge causes specific eicosanoid response in aspirin-sensitive asthmatics. Am J Respir Crit Care Med. 1996 Dec;154(6 Pt 1):1608–1614. doi: 10.1164/ajrccm.154.6.8970343. [DOI] [PubMed] [Google Scholar]
  15. Szczeklik A., Stevenson D. D. Aspirin-induced asthma: advances in pathogenesis and management. J Allergy Clin Immunol. 1999 Jul;104(1):5–13. doi: 10.1016/s0091-6749(99)70106-5. [DOI] [PubMed] [Google Scholar]

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