Figure 3.
APP protein and Aβ-42 peptide amino-acidic sequence. APP Cu-binding site is described. Amino acids involved in the binding are highlighted. Aβ-peptide sequence is presented; key amino acids are indicated in red. His6, Tyr10, His13 and His14, located at the hydrophilic N-terminal, constitute the metal-binding site; Met35 at the lipophilic C-terminal corresponds to the metal-reducing site.
