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. 2005 Oct 3;146(8):1041–1059. doi: 10.1038/sj.bjp.0706416

Figure 3.

Figure 3

APP protein and Aβ-42 peptide amino-acidic sequence. APP Cu-binding site is described. Amino acids involved in the binding are highlighted. Aβ-peptide sequence is presented; key amino acids are indicated in red. His6, Tyr10, His13 and His14, located at the hydrophilic N-terminal, constitute the metal-binding site; Met35 at the lipophilic C-terminal corresponds to the metal-reducing site.