TABLE 2.
Lesion indices observed at the cecal-colonic junction
| Expt | Infection status | Mouse | n | Severity score fora:
|
Lesion indexa | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Time point | Inflammation | Edema | Epithelial defect | Hyperplasia | Dysplasia | |||||
| 1 | H. rodentium | Male IL-10−/− | 11 | 3-6 wk | 2 (0-3) | 1 (0-1.5) | 0.5 (0-2.5) | 1 (0-3) | 0.5 (0-2) | 6 (0-10) |
| Female IL-10−/− | 7 | 4-6 wk | 1 (0-2.5) | 1 (0-1.5) | 0 (0-1.5) | 0.5 (0-2.5) | 0 (0-1.5) | 2 (0-9) | ||
| H. rodentium and H. trogontum | Male IL-10−/− | 12 | 1-3 wk | 2.5 (0-2.5) | 1.75 (0.5-3) | 2.5 (0-3) | 1.5 (0-2.5) | 1.25 (0-2) | 9.75 (0.5-11.5) | |
| Female IL-10−/− | 13 | 2-6 wk | 0 (0-2) | 0 (0-3) | 0 (0-2.5) | 0 (0-2) | 0 (0-1.5) | 0 (0-10.5) | ||
| 2 | Uninfected controls | Male B6 | 5 | 4 wk | 0 (0) | 0 (0-0.5) | 0 (0) | 0 (0) | 0 (0) | 0 (0-0.5) |
| Female B6 | 4 | 4 wk | 0 (0) | 0 (0-0.5) | 0 (0) | 0 (0) | 0 (0) | 0 (0-0.5) | ||
| H. trogontum | Male B6 | 4 | 4 wk | 0 (0-0.5) | 0 (0-0.5) | 0.5 (0-1) | 0 (0) | 0 (0) | 0 (0-1) | |
| Female B6 | 5 | 4 wk | 0 (0-0.5) | 0.5 (0-1) | 0 (0) | 0 (0) | 0 (0) | 0.5 (0-1.5) | ||
| Uninfected controls | Male IL-10−/− | 5 | 4 wk | 0 (0) | 0 (0-0.5) | 0 (0) | 0 (0) | 0 (0) | 0 (0-0.5) | |
| Female IL-10−/− | 5 | 4 wk | 0 (0-1) | 0 (0-2.5) | 0 (0-0.5) | 0 (0) | 0 (0) | 0 (0-4) | ||
| H. trogontum | Male IL-10−/− | 5 | 2-3 wk | 2.5 (2.5-3) | 2 (1.5-2) | 2.5 (2-3) | 1 (0.5-2) | 1 (0.5-1.5) | 8.5 (7.5-11) | |
| Female IL-10−/− | 3 | 3-4 wk | 2 (1-2.5) | 2 (1.5-2.5) | 1.5 (0-2) | 0.5 (0-1.5) | 0.5 (0-1) | 7 (2.5-9) | ||
| 3 | Uninfected controls | Male IL-10−/− | 5 | 8 days | 0 (0-0.5) | 0 (0-0.5) | 0 (0) | 0 (0) | 0 (0) | 0 (0-0.5) |
| Female IL-10−/− | 6 | 8 days | 0 (0) | 0 (0-0.5) | 0 (0) | 0 (0) | 0 (0) | 0 (0-0.5) | ||
| H. trogontum | Male IL-10−/− | 10 | 8 days | 2.5 (0-3) | 2.25 (0-3.5) | 2.5 (0-3.5) | 1.5 (0-2) | 0.5 (0-1) | 9.75 (0-13) | |
| Female IL-10−/− | 10 | 8 days | 3 (1-3.5) | 2 (0-2.5) | 3 (0-3.5) | 1.75 (0-2) | 1 (0-1) | 10 (1-12.5) | ||
Values are medians and ranges.