Table 4. Simulated membrane currents and rate constants for binding, desensitization and gating for selected GABA_A receptor agonists.

The rate constants were empirically determined (see Methods) and the simulated currents were obtained for the receptor model using ModelMaker3. The agonist concentrations used were (µM): 3, 8, 20, 50, 120, 300 for GABA; 10, 25, 60, 160, 400, 1000 for THIP; 10, 30, 100, 300, 1000, 3000 for P4S; and 300, 1200, 2100, 3000 for 4-PIOL. The duration of application was set to 5 s.