Figure 2. Diltiazam blocks the MET current, slowing adaptation and showing some evidence for open channel block.
A, stimulus shown at top, with upward indicating towards kinocilium, MET currents for control (black, upper panel), 100 μm diltiazem (grey, middle traces) and 300 μm diltiazem (lower, dark grey traces) are shown. Scale bar near control traces should be used for all drug doses. B, expanded view of the smallest response to hair bundle deflection, demonstrating that fast adaptation slows as the MET current was reduced. C, expanded view of largest stimulus demonstrating that in the presence of the drug, the current shows a rapid decrease in amplitude, indicative of an open channel block.