Figure 1. Effect of VR-1 agonists (RTX and CAP) and CPC on the rat chorda tympani response to NaCl.
The tongue was stimulated with a rinse solution (R; 10 mm KCl) and with 100 mm NaCl + 10 mm KCl (N) or with 100 mm NaCl + 10 mm KCl + 5 μm Bz (N + Bz). A, the Bz-insensitive NaCl chorda tympani response was enhanced (d–e) by 1 μm RTX and inhibited (j–k) by 10 μm RTX. B, increasing concentrations of RTX (•), CAP (▪) and CPC (▴) produced biphasic changes in the Bz-insensitive NaCl chorda tympani response. Each point represents the mean ± s.e.m. of the normalized chorda tympani response from 3 animals.