FIG. 6.
Competition between wild-type Y. pseudotuberculosis and yop mutants at 5 days postinfection with 2 × 109 CFU of a mixture of equal amounts of the wild-type strain and either yopB, yopH, yopE, yopO, or yopHEMOJ. Data from six to eight mice from three to four experiments were pooled. Each point represents the C.I. [(mutant/wild-type output ratio)/(mutant/wild-type input ratio)] value for the tissue sample from one mouse. Shaded bars represent the geometric means of the C.I. values. Open symbols indicate that the yop mutant was below the limit of detection, which was usually 200 bacteria. Asterisks indicate the yop mutants that were significantly outcompeted by wild-type bacteria (*, P = 0.1 to 0.01; **, P < 0.01).