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Experimental design for PA-824 efficacy against M. leprae in BALB/c and nude mouse footpad models
| Model and treatment (mg/kg) | No. of mice | Harvest time(s) postinfection (wk) |
|---|---|---|
| BALB/c mice | ||
| Untreated control | 20 | 8, 12, 20, 24 |
| CM-2 control | 10 | 20, 24 |
| Rifampin (8) | 10 | 20, 24 |
| PA-824 (100) | 10 | 20, 24 |
| PA-824 (25) | 10 | 20, 24 |
| Nude mice | ||
| Untreated control | 5 | 24 |
| Rifampin (8) | 5 | 24 |
| PA-824 (100) | 5 | 24 |
