Table 3. .
Power of Survey Study of 363 Individuals to Detect an Effect Similar to That Observed at ITPR3, as Computed by Monte Carlo Analysis[Note]
| No. of Simulated Survey Studies with P < |
||||||
| Subject Group |
Case Genotype Ratios Determining Frequencies | .05 | .01 | .001 | .000168 | .0001 |
| Cases | 39:81:61 | 993 | 958 | 790 | 558 | 469 |
| Intermediate 1 | 36:81:63 | 981 | 880 | 573 | 321 | 257 |
| Intermediate 2 | 34:82:66 | 944 | 751 | 364 | 154 | 120 |
| Intermediate 3 | 31:82:68 | 816 | 570 | 184 | 51 | 38 |
| Intermediate 4 | 29:82:71 | 682 | 348 | 65 | 11 | 6 |
| Intermediate 5 | 26:83:73 | 449 | 168 | 23 | 4 | 1 |
| Intermediate 6 | 23:83:75 | 263 | 62 | 2 | 0 | 0 |
| Intermediate 7 | 21:83:78 | 85 | 8 | 0 | 0 | 0 |
| Intermediate 8 | 18:83:80 | 29 | 3 | 0 | 0 | 0 |
| Intermediate 9 | 16:84:83 | 4 | 0 | 0 | 0 | 0 |
| Controls | 13:84:85 | 4 | 0 | 0 | 0 | 0 |
Note.— Each row represents the result of 1,000 simulations of data for a single locus, with the case genotype frequencies drawn from a trinomial distribution reflecting the observed case frequencies (top row of data), the observed control frequencies (bottom row), or nine intermediate frequency sets. The frequencies of the simulated control genotypes were the frequencies of the observed control genotypes for all rows. As expected, approximately half of the time (558 of 1,000 simulations), we would have observed a more significant P value than we actually did for rs2296336 (P=.000168), if the true genotype frequencies were our observed frequencies.