Abstract
In a controlled trial chloramphenicol proved as effective and much cheaper than penicillin for the treatment of group A meningococcal meningitis in Zaria, Nigeria. A short course of five days cured most patients. Adults and older children were soon able to take chloramphenicol by mouth, which reduced the cost and simplified treatment.
It is suggested that chloramphenicol is a suitable alternative to sulphonamides for the treatment of meningococcal meningitis in those parts of Africa where the organism is sulphonamide-resistant.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bulos N. K. Efficacy of intramuscular chloramphenicol in treatment of H. influenzae meningitis. J Pediatr. 1972 Aug;81(2):416–417. doi: 10.1016/s0022-3476(72)80347-0. [DOI] [PubMed] [Google Scholar]
- DEANE G. E., FURMAN J. E., BENTZ A. R., WOODWARD T. E. Treatment of meningitis with chloromycetin palmitate; results of therapy in twenty-three cases. Pediatrics. 1953 Apr;11(4):368–380. [PubMed] [Google Scholar]
- DuPont H. L., Hornick R. B., Weiss C. F., Snyder M. J., Woodward T. E. Evaluation of chloramphenicol acid succinate therapy of induced typhoid fever and rocky mountain spotted fever. N Engl J Med. 1970 Jan 8;282(2):53–57. doi: 10.1056/NEJM197001082820201. [DOI] [PubMed] [Google Scholar]
- EICKHOFF T. C., FINLAND M. CHANGING SUSCEPTIBILITY OF MENINGOCOCCI TO ANTIMICROBIAL AGENTS. N Engl J Med. 1965 Feb 25;272:395–398. doi: 10.1056/NEJM196502252720804. [DOI] [PubMed] [Google Scholar]
- Greenwood B. M., Whittle H. C., Dominic-Rajkovic O. Counter-current immunoelectrophoresis in the diagnosis of meningococcal infections. Lancet. 1971 Sep 4;2(7723):519–521. doi: 10.1016/s0140-6736(71)90439-9. [DOI] [PubMed] [Google Scholar]
- Lefèvre M., Sirol J., Vandekerkove M., Faucon R. Données biologiques et cliniques concernant le comportement de Neisseria meningitidis A vis-à-vis de quelques sulfamides et antibiotiques: observations faites à Fort-Lamy (Tchad) lors d'une poussée saisonnière de meningite cérébro-spinale. Bull World Health Organ. 1969;40(3):331–342. [PMC free article] [PubMed] [Google Scholar]
- PARKER R. T., SNYDER M. J., LIU R. S., LOOPER J. W., Jr, WOODWARD T. E. Therapeutic range of chloramphenicol in purulent meningitis. Antibiotic Med Clin Ther (New York) 1955 Apr;1(4):192–200. [PubMed] [Google Scholar]
- Sanborn W. R. Sulfa-drug resistance and serologic studies of a meningococcal meningitis epidemic. J Egypt Public Health Assoc. 1969;44(4):356–368. [PubMed] [Google Scholar]
- Sorensen K. General review of the treatment of meningitis. J Egypt Public Health Assoc. 1969;44(4):408–424. [PubMed] [Google Scholar]
- Wallerstein R. O., Condit P. K., Kasper C. K., Brown J. W., Morrison F. R. Statewide study of chloramphenicol therapy and fatal aplastic anemia. JAMA. 1969 Jun 16;208(11):2045–2050. [PubMed] [Google Scholar]