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Ad genome concatemer formation. A549 cells were infected with wild-type or mutant viruses at a multiplicity of 200 particles per cell. Cells were harvested 36 h after infection, solidified in agarose plugs, and treated with SDS-proteinase K solution. The DNA were separated on 1.0% agarose by pulsed-field gel electrophoresis and transferred to Hybond-N. Viral unit-length genome and multimers were hybridized with 32P-labeled Ad genomic probe. Uninf., uninfected; D, dimer; M, monomer.
