TABLE 1.
In vivo antifungal pharmacodynamic characterizations
| Drug class | Time course of activity
|
Pharmacodynamic parameter
|
||
|---|---|---|---|---|
| Killing | PAE | Type | Magnitudea | |
| Triazole | Static | Long | AUC/MIC | 25 |
| Polyene | Cidal | Long | Peak/MIC | 4 (10) |
| Flucytosine | Static | Short | T > MIC | 25b |
| Echinocandin | Cidal | Long | Peak/MIC | 3 (10) |
| Sordarin | NAc | NA | AUC/MIC | NA |
a
The magnitude end point is the dose necessary to achieve 50% of the maximal effect. The data represent the ratio for AUC/MIC and the percentage of the dosing interval for T > MIC.
b
Dose associated with maximal efficacy.
c
NA, not available.