Table 1.
Physiological properties and dopaminergic modulation of EPSP in P-NPFS and P-P connections
| P-NPFS
|
P-P
|
|||||
|---|---|---|---|---|---|---|
| Control (n = 21) | DA (n = 21) | P value | Control (n = 13) | DA (n = 13) | P value | |
| EPSP amplitude, mV | 1.71 ± 0.16 | 1.67 ± 0.19 (−2.34%) | 0.577 | 0.86 ± 0.12** | 0.57 ± 0.13 (−35.7%) | 0.001* |
| EPSP delay, ms | 0.68 ± 0.08 | — | — | 1.39 ± 0.20** | — | — |
| EPSP 20–80% rise time, ms | 1.17 ± 0.08 | — | — | 1.84 ± 0.21** | — | — |
| EPSP decay, ms | 10.7 ± 0.83 | 15.3 ± 0.79 | 0.121 | 51.1 ± 7.59** | 47.6 ± 6.48 | 0.619 |
| Failure rate, % | 6.9 ± 1.80 | 9.7 ± 2.20 | 0.190 | 5.4 ± 1.74 | 22.7 ± 5.71 | 0.002* |
| CV | 0.35 ± 0.02 | 0.36 ± 0.02 | 0.684 | 0.46 ± 0.05 | 0.86 ± 0.18 | 0.013* |
| Membrane potential of postsynaptic neurons, mV | −69.0 ± 1.31 | −67.5 ± 1.25 | 0.043* | −65.0 ± 1.40 | −62.7 ± 1.69 | 0.007* |
| Threshold of postsynaptic cells, mV | −47.4 ± 2.32 | −48.7 ± 2.27 | 0.295 | −40.8 ± 1.26** | −42.3 ± 1.60 | 0.272 |
| After hyperpolarization (AHP) | 12.0 ± 0.97 | 12.4 ± 1.09 | 0.127 | — | — | — |
*
, P < 0.05 between control and dopamine (DA);
**
, P < 0.05 between controls of P-NPFS and P-P.