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The effect of endogenous IFN-γ on long-term cardiac allograft survival induced by CD28-B7 blockade in a MHC-mismatched (BALB/c into C57BL/6) combination (a) or a minor-mismatched (129 into C57BL/6) combination (b). Wild-type or IFN-γ–/– recipients were treated with or without CTLA4Ig (250 μg intraperitoneally on days 0, 2, 4, and 6 after transplantation) as described in Methods. *P = 0.205; **P = 0.003.
