FIG. 1.
Primary structure of the human myocardin gene and alignment of the deduced amino acid sequences of the human and murine myocardin proteins. (A) A schematic map of the human myocardin gene structure. Performing a Blast search of the GenBank database identified the human myocardin gene. The myocardin gene is located on human chromosome 17 and is identified as GenBank accession number AC005358. Exons are shown as vertical boxes. The initiation codon (ATG) in exon 5 is shown. A 10-kb scale is shown below the map. (B) Alignment of the deduced amino acid sequences of the deduced human and murine myocardin proteins. The deduced amino acid sequence of mouse myocardin is shown below the sequence of the human myocardin protein. The conserved amino acid residues are shaded dark gray. The conserved basic domain (light gray box), polyglutamine tract (underline), and SAP box (black box) are shown.