Figure 6.
Morphological changes in hSec10 overexpressing cells, as shown by EM. (a and b) hSec10 overexpressing cells were vertically elongated (a) compared with control cells (b). (c and d) Increased numbers of vesicles were seen at the apical plasma membrane in hSec10 overexpressing cells (c) compared with controls (d). Increased numbers of vesicles were also seen basolaterally (Lipschutz and Mostov, unpublished observations). Arrows point to examples of 50–100-nm vesicles found within 500 nm of the plasma membrane. a and b and c and d were taken at equal magnifications. Bar, 1 μm.