. 2006 Jun 14;103(26):10086–10091. doi: 10.1073/pnas.0603615103

Table 1.

Cardiac dysfunction in response to TAC in PGC-1α^−/− (KO) mice

Echo parameter	WT		KO		WT TAC		KO TAC		P^*	P^†	P^‡
Echo parameter	Average	SEM	Average	SEM	Average	SEM	Average	SEM	P^*	P^†	P^‡
Heart rate, bpm	670	18	644	25	671	66	524	27	NS	NS	0.07
LVAW	103	3	97	4	130	8	93	4	NS	<0.004	<0.007
LVEDD	279	15	288	8	285	21	565	21	NS	NS	<0.0003
LVESD	94	16	107	6	143	34	493	22	NS	NS	<0.0003
FS	68	4	63	2	51	9	13	1	NS	NS	<0.004

PGC-1α WT and KO mice underwent TAC as described in Methods. Shown are average values for the indicated echocardiographic parameter from WT and KO mice without or 2 months after TAC (n = 5 in each group). LVAW, × 10⁻⁵ m. LVEDD, × 10⁻⁵ m; LVESD, × 10⁻⁵ m; FS, see Fig. 1 for derivation. NS, nonsignificant.

*KO vs. WT.

^†WT TAC vs. WT.

^‡KO TAC vs. KO.