Fig. 2.
PGC-1α−/− (KO) mice develop dilated cardiomyopathy in response to TAC. Hearts from the animals described in Fig. 1 were excised 2 months after TAC. (A) Photographs of sample WT and KO hearts with and without TAC. (B) Low-magnification views of hematoxylin/eosin stains of transverse sections of the same hearts as in A. (C) Average weights of hearts from all mice described in Fig. 1. (D) Sample higher-magnification views of trichrome stains from the same hearts as in B. Blue indicates the accumulation of extracellular matrix or fibrosis. (Magnifications: ×20.)