Fig. 2.
Drosophila SOL1 modulates C. elegans GLR-1-mediated current. (A) The predicted amino acid sequences encoded by C. elegans sol-1 and Drosophila sol1. Amino acids are numbered beginning with the first predicted methionine. Predicted transmembrane domains at the C terminus and CUB domains are indicated by gray and black underlines, respectively. (B) Currents measured in response to 1 mM glutamate application in Xenopus oocytes that expressed GLR-1 and STG-1 or GLR-1 and STG-1 coexpressed with either Ce SOL-1 or Dro SOL1 before (black) and after (red) preincubation with Con-A. Oocytes were voltage-clamped at −70 mV. (C) Average peak current (black) and current 1 s after the beginning of glutamate application (gray).