Table 5.
Multivariate survival analysis of the comprehensive test set of MPM tumors
| Variable | Hazard ratio (95% CI) | P |
|---|---|---|
| Mixed (nonepithelial) cell type | 1.38 (0.67-2.84) | 0.38 |
| Extrapleural lymph node metastasis | 1.21 (0.54-2.73) | 0.64 |
| Positive resection margins | 3.29 (0.78-13.98) | 0.11 |
| Prognostic test | 2.06 (0.75-5.62) | 0.16 |
NOTE: Hazard ratios and P values were generated by fitting a Cox proportional hazards regression model to censored survival data (n = 52) as described in Materials and Methods. Clinical variables were converted to binary format and column codings used in multivariate analysis can be found in Supplemental Table S3. The “Prognostic test” variable refers to predictions made using the combination of four optimal expression ratios according to criteria outlined in Materials and Methods and Results.