Table 1.
Multivariate survival analysis of MPM tumors using a previously validated ratio-based prognostic test
| Variable | Hazard ratio (95% CI) | P |
|---|---|---|
| Mixed (nonepithelial) cell type | 1.49 (0.62-3.60) | 0.37 |
| Extrapleural lymph node metastasis | 2.34 (0.77-7.16) | 0.14 |
| Positive resection margins | 1.23 (0.33-4.65) | 0.76 |
| Prognostic test | 2.00 (0.79-5.09) | 0.14 |
NOTE: Hazard ratios and P values were generated by fitting a Cox proportional hazards regression model to censored survival data linked to specimens profiled in the current study (n = 39) as detailed in Materials and Methods. Clinical variables were converted to binary format and column codings used in multivariate analysis can be found in Supplemental Table S2. The “Prognostic test” variable refers to predictions made using a previously described (ref. 12) combination of three prognostic expression ratios according to criteria outlined in Results.
Abbreviation: 95% CI, 95% confidence interval.