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. Author manuscript; available in PMC: 2006 Oct 7.
Published in final edited form as: Science. 2006 Apr 7;312(5770):117–121. doi: 10.1126/science.1124287

Fig. 4.

Fig. 4

Postnatal losartan treatment of lung disease in Fbn1C1039G/+ mice. Histologic analysis of lung in wild-type mice (A) shows normal airspace caliber. Fbn1C1039G/+ mice treated with placebo (B) show diffuse distal airspace widening (example delineated with arrows). Distal airspace caliber is reduced in Fbn1C1039G/+ mice treated with losartan (C). Scale bars, 500 μm. (D) Average mean linear intercept, a marker of airspace caliber, is greater for placebo-treated Fbn1C1039G/+ mice than for untreated wild-type and losartan-treated Fbn1C1039G/+ mice. *P < 0.01, **P < 0.001.