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. 2006 Jun 15;116(7):1935–1945. doi: 10.1172/JCI27745

Figure 1. CTLA4 blockade enhances Teff proliferation in vitro.

Figure 1

CD4+CD25+ Tregs and CD4+CD25– Teffs were isolated from lymph nodes and stimulated in vitro with irradiated T cell–depleted splenocytes in the presence of 10 μg/ml anti-CD3 in the presence or absence of 50 μg/ml anti-CTLA4 monoclonal antibody. [3H]thymidine was added for the last 8 hours of a 72-hour culture. The data are representative of 3 independent experiments.