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Haploinsufficiency for Tgfb1 increases papilloma incidence. Twenty-three WT and 30 Tgfb1+/− age-matched adult female mice were subjected to a standard chemical carcinogenesis protocol, and papilloma numbers were counted weekly. Tgfb1+/− developed significantly more papillomas than Tgfb1+/+ mice (P = 0.025 at 20 weeks; Student’s t test).
