Figure 7. Hes1 represses Ngn3 and Ptf1a in parallel in the developing CBD epithelium.
Ngn3 was not expressed in the developing CBD epithelium at E12.5 in WT mice (A and E) and Ptf1acre/cre mice (C and G). Ectopic Ngn3 expression was observed in the ectopic pancreatic rudiment in the CBD region at E12.5 in both Hes1-null mice (B and F) and Hes1/Ptf1a double-null mice (D and H). Arrows indicate the developing CBD (A, C, E, and G) and the ectopic pancreatic rudiment in the CBD region (B, D, F, and H). Scale bars: 50 μm.