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. 2006 May 18;116(6):1484–1493. doi: 10.1172/JCI27704

Figure 4. Estimation of Ptf1a lineage–labeled ratio in ectopic pancreatic cells.

Figure 4

Histological analysis using the thin (3-μm) sections indicated coexpression of β-galactosidase and pancreatic markers (amylase, insulin, glucagon, and somatostatin) in the ventral pancreas in Hes1wt/wtPtf1acre/wtROSA26r mice (A) and in the CBD region (ectopic pancreas) in Hes1–/–Ptf1acre/wtROSA26r mice (B) at E17.5. Arrows indicate Ptf1a lineage–negative pancreatic endocrine cells. The calculated percentage of Ptf1a lineage labeling in each of the cell types was similar in Hes1wt/wtPtf1acre/wtROSA26r and Hes1–/–Ptf1acre/wtROSA26r mice (see Results). Scale bars: 50 μm.