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(A) The genomic structure of the dSmg1 gene, showing the position of the nonsense mutations in dSmg1rst1 (codon 2253 AAA → TAA) and dSmg1rst2 (codon 704 AAA → TAA) alleles. (B) The predicted ORFs of wild-type and mutant dSmg1. The three characteristic domains of PIKKs—FAT, PI3Kc, and FATC—are shown (Bosotti et al. 2000).
