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. 1992 Sep;77(1):147–149.

Neutrophil priming by hepatocyte growth factor, a novel cytokine.

W Jiang 1, M C Puntis 1, T Nakamura 1, M B Hallett 1
PMCID: PMC1421591  PMID: 1398762

Abstract

We demonstrate here that the recently defined cytokine hepatocyte growth factor (HGF) 'primes' human neutrophils. Recombinant human HGF over the concentration range 0.1-20 ng/ml increased the neutrophil response to f-met-leu-phe by up to 200%, and required only a short preincubation, 10 min producing the maximum effect. Priming was independent of changes in cytosolic-free calcium homeostasis. We conclude that HGF may be a physiologically important cytokine with 'priming' activity for neutrophils.

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Selected References

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