Fig. 2.
Conservation of miR-124a. (A) Comparison of miR-124astem-loop precursor sequences across species. Nucleotides conserved across all species are shown in dark gray, and regions conserved in vertebrates, but not in invertebrates, are in light gray. The box indicates the sequence of mature miR-124a. (B) Predicted stem-loop precursors for each miRNA are depicted as short filled rectangles with a vertical bar representing the mature miRNA. miR-124a-1 and -124a-2 are located within GenBank transcripts, and miR-124a-3 is located within a mouse EST (arrows indicate direction of transcription). Alignment scores, indicated by black bars in the conservation track, show that the three miR-124a loci are located in conserved regions of the mouse genome (UCSC, Mm5 assembly).