Abstract
An attempt has been made to evaluate the role of macrophages from rabbits rendered tolerant in neonatal life to BGG in the immune response. The results show that macrophages from a tolerant rabbit took up the antigen to which it was tolerant and stimulated a specific response in the rate of DNA synthesis by spleen cells from an immunized animal. Whatever the role macrophages play in the immune response, no obvious defect of recognition of the antigenic molecules was demonstrated and this would agree with in vivo experiments using rats and a bacterial antigen (Nossal and Ada, 1964), where tolerant animals were able to recognize antigen in a manner characteristic of immune animals.
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Selected References
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- DUTTON R. W., EADY J. D. AN IN VITRO SYSTEM FOR THE STUDY OF THE MECHANISM OF ANTIGENIC STIMULATION IN THE SECONDARY RESPONSE. Immunology. 1964 Jan;7:40–53. [PMC free article] [PubMed] [Google Scholar]
- HUMPHREY J. H. IMMUNOLOGICAL UNRESPONSIVENESS TO PROTEIN ANTIGENS IN RABBITS. I. THE DURATION OF UNRESPONSIVENESS FOLLOWING A SINGLE INJECTION AT BIRTH. Immunology. 1964 Jul;7:449–461. [PMC free article] [PubMed] [Google Scholar]
- Harris G. Studies of the mechanism of antigen stimulation of DNA synthesis in rabbit spleen cultures. Immunology. 1965 Dec;9(6):529–541. [PMC free article] [PubMed] [Google Scholar]
- MARK R., DIXON F. J. ANTI-BOVINE SERUM ALBUMIN FORMATION BY TRANSFERRED HYPERIMMUNE MOUSE SPLEEN CELLS. J Immunol. 1963 Nov;91:614–620. [PubMed] [Google Scholar]
- Mäkelä O., Mitchison N. A. The effect of antigen dosage on the response of adoptively transferred cells. Immunology. 1965 Jun;8(6):549–556. [PMC free article] [PubMed] [Google Scholar]
- NOSSAL G. J., ADA G. L. RECOGNITION OF FOREIGNNESS IN IMMUNE AND TOLERANT ANIMALS. Nature. 1964 Feb 8;201:580–582. doi: 10.1038/201580a0. [DOI] [PubMed] [Google Scholar]
- Nossal G. J. Self-recognition. Ann N Y Acad Sci. 1965 Jun 30;124(1):37–49. doi: 10.1111/j.1749-6632.1965.tb18940.x. [DOI] [PubMed] [Google Scholar]
- ROWLEY D. A., FITCH F. W. THE MECHANISM OF TOLERANCE PRODUCED IN RATS TO SHEEP ERYTHROCYTES. II. THE PLAQUE-FORMING CELL AND ANTIBODY RESPONSE TO MULTIPLE INJECTIONS OF ANTIGEN BEGUN AT BIRTH. J Exp Med. 1965 May 1;121:683–695. doi: 10.1084/jem.121.5.683. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SERCARZ E. E., COONS A. H. THE ABSENCE OF ANTIBODY-PRODUCING CELLS DURING UNRESPONSIVENESS TO BSA IN THE MOUSE. J Immunol. 1963 Mar;90:478–491. [PubMed] [Google Scholar]