TABLE 1.
Caspofungin MIC distribution for 8,197 isolates of Candida spp. collected from 91 institutions between 2001 and 2004a,b
| Species | No. of isolates tested | Cumulative % at MIC (μg/ml)
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.007 | 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | >8 | ||
| C. albicans | 4,454 | 22 | 45 | 80 | 98 | 99 | 99 | 99 | 99 | 99 | 100 | ||
| C. glabrata | 1,120 | 1 | 6 | 64 | 96 | 99 | 99 | 99 | 99 | 99 | 100 | ||
| C. tropicalis | 911 | 12 | 37 | 79 | 96 | 99 | 99 | 99 | 99 | 99 | 99 | 99 | 100 |
| C. kefyr | 38 | 18 | 87 | 97 | 100 | ||||||||
| C. pelliculosa | 25 | 4 | 56 | 92 | 100 | ||||||||
| C. parapsilosis | 1,158 | 1 | 1 | 1 | 4 | 13 | 49 | 90 | 99 | 99 | 100 | ||
| C. krusei | 238 | 1 | 39 | 65 | 88 | 98 | 99 | 100 | |||||
| C. guilliermondii | 107 | 1 | 5 | 19 | 39 | 82 | 94 | 96 | 96 | 96 | 100 | ||
| C. lusitaniae | 105 | 2 | 4 | 8 | 48 | 84 | 98 | 99 | 99 | 100 | |||
| Candida spp.c | 41 | 2 | 17 | 37 | 51 | 78 | 88 | 95 | 98 | 100 | |||
| All species | 8,197 | 13 | 30 | 62 | 80 | 84 | 91 | 98 | 99 | 99 | 99 | 99 | 100 |
a
All isolates tested in RPMI 1640 broth with 24-h incubation and a prominent reduction endpoint criteria (MIC-2).
b
All isolates were from blood or normally sterile site infections.
c
Includes C. famata (12 isolates), C. rugosa (8 isolates), C. dubliniensis (10 isolates), C. lipolytica (7 isolates), and C. zeylanoides (4 isolates).