Table 1.
Progressive enhancement of expanded polyQ toxicity in pqe-1 mutant animals
| Genotype | Lines | % defective, 3 days | % defective, 8 days |
|---|---|---|---|
| Htn-Q150 | 13 | 0 | 13+/−4 |
| pqe-1(rt13) | — | 0 | 0 |
| pqe-1(rt13); Htn-Q2 | 5 | 1+/−1 | 5+/−1 |
| pqe-1(rt13); Htn-Q23 | 5 | 0 | 2+/−1 |
| pqe-1(rt13); Htn-Q95 | 5 | 7+/−2 | 36+/−7 |
| pqe-1(rt13); Htn-Q150 | 4 | 73+/−5 | 88+/−4 |
The genotype and huntingtin transgene are listed in column 1; the number of transgenic lines scored is listed in column 2. The huntingtin fragments were expressed from extrachromosomal arrays by using the osm-10 promoter. The average percentage of ASH neurons affected (dye-filling defective) in adult animals is reported (in columns 3 and 4) at 3 and 8 days. More than 150 ASH neurons were scored for each data point. The SEM is listed.