Fig 5.
MPTP-induced DA efflux is deficient in α-synuclein null mice. (A) In vivo microdialysis of striatal dopamine efflux after a single i.p injection of 30 mg/kg MPTP. Gray circle, wild type; black circle, α-synuclein−/−. (B) α-Synuclein mutant mice display normal amphetamine-induced DA release. Legend as in A. Microdialysis values are represented as a percentage of the average of four baseline measurements taken in the hour preceding MPTP injection; each animal was used as its own baseline control. There were no significant differences in baseline values. n = 3–8 mice per genotype.