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. 2026 Jul 15;21:594. doi: 10.1186/s13018-026-07093-8

Table 4.

Risk factors for dedifferentiated chondrosarcoma on multivariate analysis

Imaging feature OR 95% CI (Low) 95% CI (High) Coefficient p-Value
Pathologic fracture 4.911 0.726 33.208 1.592 0.103
> 2/3 Endosteal scalloping 5.277 0.756 36.890 1.635 0.094
Medullary expansion 0.271 0.050 1.481 − 1.315 0.133
Periosteal reaction 3.663 0.783 17.134 1.241 0.099
Cortical thickening 4.690 0.860 25.572 1.526 0.074
Marrow edema 8.586 1.707 43.188 2.263 0.0091*
Soft-tissue involvement 1.444 0.276 7.554 0.324 0.664
Intercept − 4.398 < 0.001*

* Significant at p < 0.05