Table 1:
Characteristics of 48 Infants with confirmed cCMV Infection
| Characteristics | Total N=48 |
|---|---|
| Sex – n/N (%) | |
| Male | 26/48 (54) |
| Female | 22/48 (46) |
| Race and Ethnicity – n/N (%) | |
| Hispanic or Latino | 12/48 (25) |
| Non-Hispanic White | 23/48 (48) |
| Non-Hispanic Black | 8/48 (17) |
| Non-Hispanic Other1 | 2/48 (4) |
| Not reported | 3/48 (6) |
| Birth Information – Median (IQR) | |
| Gestational age, weeks | 38.7 (36.1, 39.2) |
| Birth weight, grams | 2570 (2215, 3140) |
| Birth length, cm | 48.3 (44.8, 49.6) |
| Head circumference, cm | 31.5 (30.0, 33.5) |
| CMV Test Specimen – n/N (%) | |
| Saliva and urine | 20/48 (42) |
| Urine only | 15/48 (31) |
| Urine and Blood | 12/48 (25) |
| Saliva and Blood | 1/48 (2) |
| Newborn Hearing Screening2 – n/N (%) | |
| Passed – n/total tested (%) | 20/45 (44) |
| Failed – n/total tested (%) | 25/45 (56) |
| Clinical Findings2 – n/N (%) | |
| SGA/IUGR4 | 24/48 (50) |
| Abnormal neuroimaging5 | 23/48 (48) |
| Thrombocytopenia | 18/48 (38) |
| SNHL | 16/48 (33) |
| Premature | 14/48 (29) |
| Microcephaly | 14/48 (29) |
| Hepatitis | 11/48 (23) |
| Abnormal muscle tone | 10/48 (21) |
| Petechiae | 8/48 (17) |
| Hepatosplenomegaly | 4/48 (8) |
| Chorioretinitis | 3/48 (6) |
| Other6 | 5/48 (10) |
| Antiviral Treatment for cCMV – n/N (%) | |
| Prescribed antivirals | 32/48 (67) |
| Antiviral course completed | 25/32 (78) |
| Antiviral toxicity – n/total treated (%) | 11/32 (34) |
| Neutropenia | 9/11 (82) |
| Anemia | 2/11 (18) |
| Hepatitis | 2/11 (18) |
Data are presented as no./Total (%) for categorical measures and median (IQR) for continuous measures.
1
Other: Asian (1) + “Race: I do not see my Race listed here; Ethnicity: Not Hispanic or Latino” (2)
2
Total excluded (3): deceased - not tested (2), or missing newborn hearing screening (1)
3
See Table S1 for study definitions.
4
SGA: Small for Gestational Age; IUGR: Intrauterine Growth Restriction
5
Cysts (16), Hemorrhage (8), Lenticulostriate vasculopathy (5), Calcification (4), Ventriculomegaly (2)
6
Other findings: CMV pneumonitis (2), Optic nerve hypoplasia (1), Cholestasis (1), Coloboma of macula (1)