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Role of ferritin and iron in the oxidative stress response. Various environmental factors, such as virus infections, cytokines, and UV radiation, enzymatically generate peroxides. Under the influence of iron ions, the peroxides are further reduced to hydroxyl radicals and other ROS that are capable of activating NF-κB. Ferritin forms an antioxidant system that traps free iron and thereby reduces the host cell response.
