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Possible sequence requirements on the GP1 for high-affinity binding to α-DG. Arenaviruses using α-DG as their major receptor have the small aliphatic amino acid leucine or isoleucine at position 260 (position numbering relative to LCMV) and a bulky aromatic amino acid, phenylalanine or tyrosine, at position 259 (presented in boldface). The consensus sequence cleavage site (tetrapeptide) between GP1 and GP2 of each arenavirus is shown underlined in italics.
