FIGURE 2.
Chromatin module and its simulation results. (A) A regulatory network for controlling inactive and active PRC2 levels. This network was used to construct a PDE model to examine the time-dependent spatial distribution of inactive and active PRC2 molecules. (B) Schematic illustration of the mapping procedure of certain chromosomal regions in one spatial dimension. The heat map represents the time evolution of the active PRC2 wave leading to homogeneous spatial profile (where the blue color represents the inactive regions, and the green color represents the active regions of the chromosome). (C) Attainment of spatial heterogeneity in terms of pinned wave by spatially modulating the more sensitive feedback coefficient γ. (D) Visualization of the pinned wave achieved through enhancement of degradation coefficient αX relative to the unpinned state. (E) A pinned wave realized by increasing the value of the feedback threshold parameter K, which has a lower sensitivity toward the dynamics of XIST molecules. Parameter values for the simulations in this figure are listed in Supplemental Table S1.