. Author manuscript; available in PMC: 2026 Sep 16.

Published before final editing as: Hypertension. 2026 Sep 14:10.1161/HYPERTENSIONAHA.126.27015. doi: 10.1161/HYPERTENSIONAHA.126.27015

Table 4.

Age relations of aortic structural stiffness and effective lumen radius.

	Aortic Eh (ln(dyne/cm))		Aortic Radius (mm)

Variable	Est. B±SE	p-value	Est. B±SE	p-value
Intercept	10.706 ± 0.190	<0.0001	−0.278 ± 0.837	0.74
Age^†	0.275 ± 0.006	<0.0001	0.624 ± 0.027	<0.0001
Age-squared	0.022 ± 0.002	<0.0001	−0.071 ± 0.008	<0.0001
Menopause groups^‡
Premenopausal	−0.089 ± 0.025	0.0003	−0.666 ± 0.108	<0.0001
Early	−0.184 ± 0.022	<0.0001	−0.635 ± 0.092	<0.0001
Average	−0.186 ± 0.017	<0.0001	−0.719 ± 0.072	<0.0001
Late	−0.227 ± 0.024	<0.0001	−0.852 ± 0.103	<0.0001
Menopause group x age interactions^‡
Premenopausal	0.037 ± 0.013	0.005	−0.128 ± 0.061	0.036
Early	−0.003 ± 0.011	0.78	−0.122 ± 0.047	0.009
Average	−0.014 ± 0.008	0.087	−0.221 ± 0.036	<0.0001
Late	−0.015 ± 0.013	0.26	−0.221 ± 0.059	0.0002

Centered at 50 years and rescaled to decades. Linear mixed models, adjusted for height, body-mass index, mean arterial pressure, heart rate, fasting blood glucose, total/high density lipoprotein cholesterol ratio, triglyceride, antihypertensive treatment, lipid-lowering medication usage, current smoking, and prevalent diabetes or cardiovascular disease. Body-mass index, fasting blood glucose, total/high density lipoprotein cholesterol ratio, and triglyceride levels were natural log transformed. Eh, Young’s modulus x wall thickness product.

^†

Men are the referent group.