Table 2. Drug Reduction Index (DRI) for KU19-19 and SKUB cell lines.
Dose reduction index (DRI) is the –fold of dose reduction possible to achieve the same cell kill if mitomycin-C and virus are used in combination. Fraction affected (Fa) is the LDx = Lethal dosex, dose needed to produce cell kill of x%, MOI = multiplicity of infection, CI = combination index.
| DRI (fold) | ||||
|---|---|---|---|---|
| NV1066 (MOI) | MMC alone (μgm/ml) | NV1066 | MMC | |
| KU1-19 Fa: | ||||
| LD50 | 0.16 | 0.72 | 12.4 | 5.5 |
| LD75 | 0.41 | 1.36 | 12.4 | 4.1 |
| LD90 | 1.05 | 2.57 | 12.4 | 3.0 |
| LD97 | 3.1 | 5.37 | 12.3 | 2.1 |
| SKUB cell kill (% control): | ||||
| LD50 | 0.043 | 1.56 | 3.6 | 13 |
| LD75 | 0.14 | 10.9 | 6.1 | 45 |
| LD90 | 0.51 | 76.9 | 10.4 | 156 |
| LD97 | 2.15 | 743 | 19.1 | 662 |