. Author manuscript; available in PMC: 2006 Jan 25.

Published in final edited form as: Diabetes. 2005 May;54(5):1598–1602. doi: 10.2337/diabetes.54.5.1598

TABLE 1.

Markers and map locations

						Hardy-Weinberg equilibrium (P)
Gene	SNP marker no.	Marker	SNP	Major allele frequency^*	SNP type	Case/control combined	Case group (n = 362)	Control group (n = 127)	NCBI location (bp)^‡	Intermarker interval (bp)
PYY 17q21	1	PYY-1746	C/T	0.522/0.549^†	5′ flank	0.86	0.64	0.67	42508208	93
	2	PYY-1653	G/C	0.549^†	5′ flank	—	—	—	42508115	2,541
	3	rs162430	C/T	0.521	Intron 3	0.86	0.68	0.72	42505574	—
Y2R 4q31	1	rs2880414	G/T	0.714	5′ UTR	0.21	0.10	0.73	156671278	13,585
	2	rs4425326	C/T	0.663	5′ UTR	0.63	0.44	0.75	156684863	4,743
	3	rs2880412	A/C	0.509	5′ UTR	0.67	0.18	0.17	156689606	874
	4	rs10517606	A/C	0.667	5′ UTR	0.43	0.30	0.85	156690480	11,690
	5	rs2880416	C/G	0.657	5′ UTR	0.47	0.14	0.25	156702170	375
	6	rs2342675	A/G	0.504	5′ UTR	0.75	0.17	0.11	156702550	4,259
	7	rs6857715	C/T	0.501	5′ UTR	0.82	0.22	0.12	156706809	1,822
	8	rs10461257	A/G	0.529	Intron	0.66	0.23	0.27	156708631	4,601
	9	A172T	G/A(A172T)	0.985	Exon 2	0.74	0.79	0.85	156713232	71
	10	rs1047214	C/T(Ile195)	0.592	Exon 2	0.42	0.77	0.04	156713303	351
	11	rs2880415	C/T(Ile312)	0.592	Exon 2	0.42	0.77	0.04	156713654	—

Major allele frequencies were obtained from severely obese case/control sample (n = 489).

^†

Major allele frequency obtained from 83 original extremely obese subjects for variation detection. Genotypes of PYY SNP2 assumed to be identical to PYY SNP1 based on direct sequencing of these 83 subjects.

^‡

NCBI builder 34.3.