| Nomenclature | DNA gyrase |
| Subunits | DNA gyrase subunit A, DNA gyrase subunit B |
| Comments | DNA gyrase is a type II DNA topoisomerase [38] and one of two enzymes of this subclass found in bacteria, the other being DNA topoisomerase 4. DNA gyrase introduces negative supercoils in closed circular double-stranded DNA in an ATP-dependent manner. This enzyme is the clinically-validated target for a number of antibacterial drug classes, including the aminocoumarins such as novobiocin and fluoroquinolones such as moxifloxacin, levofloxacin, ciprofloxacin and ofloxacin. |
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