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. Author manuscript; available in PMC: 2026 Aug 18.
Published in final edited form as: Structure. 2026 Apr 17;34(6):977–987.e2. doi: 10.1016/j.str.2026.03.005

Figure 3. ISG Subpopulation shifts associated with insulin secretory stimuli.

Figure 3.

(A) Percentage of ISG subpopulations within each stimuli condition. Each condition subpanel shows percentages normalized to the total number of ISGs in that condition, summing to 100%. (B) Blender renderings of representative cells in each stimulation condition. Every cell contains a mask of the nucleus, ISGs, and PM. ISGs are colored according to subpopulation identity. GLM: Glimepiride, GKA50: glucokinase activator 50, TAK: TAK-875, GIP: Gastric Inhibitory Polypeptide, Ex-4: Exendin-4. Error bars in all panels represent SEM. Error bars in all panels represent SEM. Asterisks by condition names indicate statistical significance relative to the “No Stimulation” condition. **p < 0.01, *p < 0.05, n.s. = not statistically significant as calculated using PERMANOVA testing.