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Fig. 4. The OB-fold can fulfill regulatory functions. (A) Pseudo-dimer of DBD-A (green) and symmetry-related DBD-B (DBD-Bsym; gold) (both DBDs derived from molecule I). The L12 loop of DBD-Bsym is in the ssDNA-binding cleft of DBD-A. The DBD-A orientation is approximately the same as in Figure 1C. (B) Functional interaction in the telomeric SSB; an OB-fold of the large subunit (fragment 344–495; green) binds an extended loop (fragment 142–194) of the small subunit (PDB entry 1OTC).
