FIG. 3.
Mean growth inhibition levels of rabbit sera raised against recombinant PpAMA1's. Groups of five rabbits each were immunized with 50 μg of either PpAMA1 FVO (solid symbols) or PpAMA1 3D7 (open symbols). Each rabbit serum was assayed individually for growth inhibition against three parasite lines (FVO [circles], 3D7 [inverted triangles], or HB3 [squares]), and the mean percent inhibition of invasion of RBCs for each group of five rabbits is shown along the y axis. GIAs for each serum were conducted at three (with HB3 parasites) or four concentrations, as shown on the x axis. Lines represent regression of homologous results (i.e., PpAMA FVO versus FVO parasites and PpAMA 3D7 versus 3D7 parasites) by use of a hyperbolic equation.